| 药典方剂生肌散的安全性评价 |
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| 引用本文： | 张长帅,付本懂,申海清,吴帅成,谢闪闪,孟庆大,韦旭斌.药典方剂生肌散的安全性评价[J].中国畜牧兽医,2011,38(3):173-175. |
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| 作者姓名： | 张长帅 付本懂 申海清 吴帅成 谢闪闪 孟庆大 韦旭斌 |
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| 作者单位： | (吉林大学畜牧兽医学院，吉林长春 130062） |
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| 摘 要： | 为了考察生肌散在临床使用中的安全性，试验通过单次及连续多次在豚鼠背部皮肤涂抹生肌散，观察生肌散对动物皮肤的刺激作用；通过连续4周在大鼠背部皮肤涂抹生肌散，观察生肌散反复多次长期使用对机体产生的亚慢性毒性作用。结果表明局部外用生肌散对皮肤刺激小，没有亚慢性毒性，在临床上可以推广使用。
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| 关 键 词： | 生肌散 刺激性 亚慢性毒性 |
Safety Evaluation of Shengji Powder in China Veterinary Pharmacopoeia |
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| ZHANG Chang-shuai,FU Ben-dong,SHEN Hai-qing,WU Shuai-cheng,XIE Shan-shan,MENG Qing-da,WEI Xu-bin.Safety Evaluation of Shengji Powder in China Veterinary Pharmacopoeia[J].China Animal Husbandry & Veterinary Medicine,2011,38(3):173-175. |
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| Authors: | ZHANG Chang-shuai FU Ben-dong SHEN Hai-qing WU Shuai-cheng XIE Shan-shan MENG Qing-da WEI Xu-bin |
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| Institution: | (College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China) |
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| Abstract: | In order to evaluate the clinical safety, Shengji powder was daubed on the back of Guinea pig to observe the irritant action by single test and continuous 7 d test. The subchronic toxicity was observed though being daubed on the back of wistar rats for continuous 4 weeks. The results showed that Shengji powder had a little irritant action and no subchronic toxicity. Therefore, it can be used extensively in clinic. |
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| Keywords: | Shengji powder irritant action subchronic toxicity |
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