Etiology and pathogenesis of necrotic enteritis |
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Authors: | S M Shane J E Gyimah K S Harrington T G Snider III |
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Institution: | (1) Department of Epidemiology & Community Health School of Veterinary Medicine, Louisiana State University, 70803 Baton Rouge, Louisiana, U.S.A.;(2) Department of Veterinary Pathology School of Veterinary Medicine, Louisiana State University, 70803 Baton Rouge, Louisiana, U.S.A. |
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Abstract: | Sporulated oocysts ofEimeria
acervulina were administered orally to cage-housed broilers at a dose of 3.5×105 resulted in mild subclinical coccidiosis.Clostridium
perfringens incorporated in feed at a level of 2.5×108 organisms/g. produced lesions characteristic of necrotic enteritis. Mortality of 8% (7/80) occurred in birds fed a ration inoculated withCl.
perfringens alone. Mortality of 35% (28/80) was observed in birds which received an oral dose ofE.
acervulina and which were fed simultaneously with a ration containingCl.
perfringens. Birds which were fed an inoculated ration two days after an oral dose ofE.
acervulina showed 41% (33/80) mortality. Birds which received an inoculated ration for two days before administration of an oral dose ofE.
acervulina demonstrated 18% mortality (15/80). Birds which were fed an inoculated ration four days after an oral dose ofE.
acervulina showed 10% mortality. Infection withE.
acervulina reduced the pH of intestinal contents with a simultaneous depression in serum protein. A 39% increase in intestinal passage time from 178 to 248 minutes occurred on the fifth day after infection withE.
acervulina. These experiments suggest that necrotic enteritis, attributed to proliferation of a toxigenic strain ofCl.
perfringens, followed intestinal stasis and minimal lesions induced by mild intestinal coccidiosis. |
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