| 低氧对水牛卵泡内膜细胞雄激素合成能力的影响 |
| |
| 引用本文： | 张俊,陈梦佳,闫茜,陈莫斯楠,李政达,卢嘉卡,石德顺,陆凤花.低氧对水牛卵泡内膜细胞雄激素合成能力的影响[J].中国兽医学报,2022(2):349-354. |
| |
| 作者姓名： | 张俊 陈梦佳 闫茜 陈莫斯楠 李政达 卢嘉卡 石德顺 陆凤花 |
| |
| 作者单位： | 1.广西大学动物科学技术学院亚热带农业生物资源保护与利用国家重点实验室 |
| |
| 基金项目： | 国家自然科学基金资助项目(31760666);广西自然科学基金资助项目(2020JJD130069)。 |
| |
| 摘 要： | 本研究采用低氧(5％O2)条件培养水牛内膜细胞,探讨低氧对水牛内膜细胞雄激素合成的影响.结果 显示,低氧能显著提高水牛内膜细胞雄激素合成相关基因(CYP11A1、CYP17A1和3β-HSD)表达和睾酮分泌水平(P＜0.05);低氧能显著增强水牛内膜细胞对促黄体素(LH)的敏感性(P＜0.05).结果 表明,低氧(5％...
|
| 关 键 词： | 低氧 水牛 内膜细胞 雄激素合成 |
Effects of hypoxia on steroidogenic competence of buffalo theca cells |
| |
| ZHANG Jun,CHEN Mengjia,YAN Xi,CHENMO Sinan,LI Zhengda,LU Jiaka,SHI Deshun,LU Fenghua.Effects of hypoxia on steroidogenic competence of buffalo theca cells[J].Chinese Journal of Veterinary Science,2022(2):349-354. |
| |
| Authors: | ZHANG Jun CHEN Mengjia YAN Xi CHENMO Sinan LI Zhengda LU Jiaka SHI Deshun LU Fenghua |
| |
| Institution: | (State Key Laboratory of Conservation and Utilization of Subtropical Agri-biore-sources,College of Animal Science and Technology,Guangxi University,Nanning 530004,China) |
| |
| Abstract: | Hypoxic culture(5% O2) was used to explore the effects of hypoxia on the androgen synthesis of buffalo theca cells(TCs).The results showed that hypoxia significantly enhanced the expression levels of androgen synthesis-related genes(CYP11 A1,CYP17 A1,and 3β-HSD) and the secretion levels of testosterone in buffalo TCs(P<0.05).Furthermore, hypoxic culture significantly strengthened the sensitivity of buffalo TCs to LH(P<0.05).Hypoxia(5% O2) promoted the steroidogenic competence of buffalo TCs mainly through facilitating the responsiveness of buffalo TCs to LH.This study provides a basis for further exploration of ovarian endocrine mechanism in buffalo. |
| |
| Keywords: | hypoxia buffalo theca cells androgen synthesis |
| 本文献已被 维普 等数据库收录！ |
|
