Studies on the constituents of Cyclanthera pedata fruits: isolation and structure elucidation of new triterpenoid saponins. |
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Authors: | N De Tommasi F De Simone G Speranza C Pizza |
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Institution: | Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Salerno, Ponte Don Melillo Invariante 11C, 84084 Fisciano (SA), Italy. |
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Abstract: | The isolation of nine triterpenoid saponins (1-9), among them six new natural compounds (1-6), from the MeOH extract of the fruits of Cyclanthera pedata is reported. All of the structures were elucidated by spectroscopic methods, including the concerted application of one-dimensional (1)H-(1)H total correlation spectroscopy, (1)H-(1)H nuclear Overhauser effect spectroscopy), and (13)C-(13)C DEPT-NMR and two-dimensional NMR techniques (double-quantum filtered correlated spectroscopy, rotating-frame Overhauser enhancement spectroscopy, heteronuclear single quantum coherence, and heteronuclear multiple bond correlation). A comparative study of seeds and fruits has been also carried out. |
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