Pharmacokinetics and bioavailability of ketoprofen when compounded with iron dextran for use in nursing piglets |
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| Authors: | Kristen J Reynolds Ron Johnson Robert M Friendship Jennifer Brown Saad Enouri Ronette Gehring Terri L O&#x;Sullivan |
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| Institution: | Department of Population Medicine (Reynolds, Friendship, O’Sullivan), Department of Biomedical Sciences (Johnson, Enouri), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada; Prairie Swine Center, Saskatoon, Saskatchewan (Brown); College of Veterinary Medicine, Kansas State University, USA; Universiteit Utrecht, The Netherlands (Gehring) |
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| Abstract: | In Canada, piglets receive analgesia to control pain after surgical castration. There is interest in examining the potential to mix non-steroidal anti-inflammatory drugs with iron dextran prior to injection to minimize piglet handling and labor. The objective of this study was to compare pharmacokinetics and the relative bioavailability of ketoprofen given alone (3.0 mg/kg IM) versus the same dose of ketoprofen mixed with iron dextran (52.8 mg/kg IM) (ketoprofen + iron dextran) before injection in piglets. Piglets 8 to 11 d old were allocated into 2 treatment groups (n = 8/group). Plasma drug concentrations were measured using mass spectrometry at 13 time points after injection. No significant differences were detected between the 2 groups when examining pharmacokinetic parameters (e.g., Cmax, Tmax, AUC) or relative bioavailability for either S- or R-ketoprofen enantiomers (P > 0.05). However, pain control efficacy and food safety studies of these formulations are required to further examine this practice. |
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