首页 | 本学科首页   官方微博 | 高级检索  
     


Adipose triglyceride lipase contributes to cancer-associated cachexia
Authors:Das Suman K  Eder Sandra  Schauer Silvia  Diwoky Clemens  Temmel Hannes  Guertl Barbara  Gorkiewicz Gregor  Tamilarasan Kuppusamy P  Kumari Pooja  Trauner Michael  Zimmermann Robert  Vesely Paul  Haemmerle Guenter  Zechner Rudolf  Hoefler Gerald
Affiliation:Institute of Pathology, Medical University of Graz, Graz, Austria.
Abstract:Cachexia is a multifactorial wasting syndrome most common in patients with cancer that is characterized by the uncontrolled loss of adipose and muscle mass. We show that the inhibition of lipolysis through genetic ablation of adipose triglyceride lipase (Atgl) or hormone-sensitive lipase (Hsl) ameliorates certain features of cancer-associated cachexia (CAC). In wild-type C57BL/6 mice, the injection of Lewis lung carcinoma or B16 melanoma cells causes tumor growth, loss of white adipose tissue (WAT), and a marked reduction of gastrocnemius muscle. In contrast, Atgl-deficient mice with tumors resisted increased WAT lipolysis, myocyte apoptosis, and proteasomal muscle degradation and maintained normal adipose and gastrocnemius muscle mass. Hsl-deficient mice with tumors were also protected although to a lesser degree. Thus, functional lipolysis is essential in the pathogenesis of CAC. Pharmacological inhibition of metabolic lipases may help prevent cachexia.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号