青霉酸毒性研究进展

青霉酸是圆弧青霉代谢产物的主要成分。现已证明,青霉酸对各种动物具有毒性,主要引起心脏、肝脏和肾脏等器官的损伤,并具有潜在致癌性。青霉酸在饲料中的含量很高,而且污染极其广泛。因此,研究青霉酸的毒性、中毒机理及与其他毒素的联合作用,对保证饲料卫生和动物健康具有很重要的意义,该文就青霉酸的器官毒性、细胞毒性、分子毒性及联合毒性的研究进行综述。

Advance in Toxicity of Penicillic Acid

Penicillic acid(PA) is the main metabolite of Penicillium cyclopium Westling, widely polluted in the feedstuff. It is proved that PA has toxicity to various animals in heart, liver, kidney and other organs damage,at the same time PA is potentially carcinogenic. Therefore, it makes a significant sense to clarify the toxicity, mechanism of poisoning and union toxicity with other mold toxins of PA.In this paper, the organ toxicity,cell toxicity,molecule toxicity and united toxicity of PA were reviewed.