Disposition of sulfonamides in food-producing animals: pharmacokinetics of sulfamerazine in cattle |
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| Authors: | GARY D. KORITZ DAVID W. A. BOURNE LEWIS W. DITTERT RICHARD F. BEVILL |
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| Affiliation: | Department of Veterinary Biosciences, College of Veterinary Medicine University of Illinois, Urbana, Illinois, 61801;*College of Pharmacy University of Kentucky, Lexington, Kentucky, 40506, U.S.A. |
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| Abstract: | The disposition of sulfamerazine in the plasma and urine of cattle was determined following single intravenous and oral doses. The averaged and the individual animal data were described by a two-compartment pharmacokinetic model. The drug was eliminated with a biological half-life of 6.2 h, primarily by renal excretion of unchanged sulfamerazine and metabolism to acetylsulfamerazine. Sulfamerazine (in solution) was absorbed with a half-life 6.7 h and with relative completeness (68%) following oral administration. |
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