| 倒千里光裂碱-BSA的合成研究 |
| |
| 引用本文： | 童德文,曹光荣,程东亮. 倒千里光裂碱-BSA的合成研究[J]. 动物医学进展, 2001, 22(4): 79-82 |
| |
| 作者姓名： | 童德文 曹光荣 程东亮 |
| |
| 作者单位： | 1. 西北农林科技大学畜牧兽医学院,
2. 兰州大学化学化工学院, |
| |
| 基金项目： | 国际科学基金资助项目 (IFS，NO2 90 6 - 1)，国家自然科学基金资助项目 (39770 5 71) |
| |
| 摘 要： | 用溴乙酸制备的活性酯与倒千里光裂碱反应，产物真空干燥后得到白色粉末状物，产率为82％。经MP、IR鉴定的结果判定，白色粉末状物为倒千里光裂碱－活性酯结合的季铵盐。季铵盐再与BSA反应，产物透析、冻干后呈白色针状结晶，按BSA计算，产率为87％，UV鉴定结果与正常的BSA相比，其空间构象发生明显改变，280nm处光吸收值显著下降，表明季铵盐已与BSA结合。
|
| 关 键 词： | 倒千里光裂碱 BSA 活性酯 季铵盐 合成 免疫 毒草 生物碱 |
| 文章编号： | 1007-5038(2001)04-0079-04 |
| 修稿时间： | 2001-05-14 |
Synthesis of Retronecine-BSA |
| |
| TONG De wen ,CAO Guang rong ,CHENG Dong liang. Synthesis of Retronecine-BSA[J]. Progress In Veterinary Medicine, 2001, 22(4): 79-82 |
| |
| Authors: | TONG De wen CAO Guang rong CHENG Dong liang |
| |
| Affiliation: | TONG De wen 1,CAO Guang rong 1,CHENG Dong liang 2 |
| |
| Abstract: | Synthesized the retronecine with active eater,which was prepared by 2 bromine acetic acid,a white powder,of which yield was 82%.The white powder was quatermary salt of retronecine ester identified by MP,IR.The quaternary salt with BSA synthesized products which was dialysed and lyophilized to obtain crystal of white needle.The yield was 87% according to BSA.Retronecine has been connected to BSA identified by UV. |
| |
| Keywords: | retronecine BSA active ester quaternary salt |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
