| 用单抗研究T细胞与牛流行性白血病发生的关系 |
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| 引用本文： | 潘耀谦,夏志平,高丰,冈田幸助. 用单抗研究T细胞与牛流行性白血病发生的关系[J]. 动物医学进展, 2001, 22(4): 75-78 |
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| 作者姓名： | 潘耀谦 夏志平 高丰 冈田幸助 |
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| 作者单位： | 1. 解放军军需大学动物科技系,
2. 日本岩手大学农学部, |
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| 摘 要： | 本试验对10头患流行性白血病病牛的不同器官的肿瘤组织，用8种单克隆抗体（McAb),TH14B、BAQ44A、PIg45A、BIg715A、PIg501E、cAct105、MM1A、AHCC125染色进行了观察。结果：病牛经临床病理学和免疫琼扩试验而诊断为EBL，通过免疫组织化学检测，在10个病例中发现有9个病例的肿瘤组织对B细胞属性的McAb有很强的染色反应，证明其来源于B细胞。仅有1个病例对B细胞属性的McAb着色很淡，而对T细胞属性的McAb着色很深，呈强阳性反应，说明其来源可能与T细胞有关。
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| 关 键 词： | 牛流行性白血病 单克隆抗体 B细胞 T细胞 |
| 文章编号： | 1007-5038(2001)04-0075-04 |
| 修稿时间： | 2001-04-23 |
T cell relation to occurrence of enzootic bovine leucosis observing by MoAb |
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| PAN Yao qian,XIA Zhi ping,GAO Feng,Kosuke Okada. T cell relation to occurrence of enzootic bovine leucosis observing by MoAb[J]. Progress In Veterinary Medicine, 2001, 22(4): 75-78 |
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| Authors: | PAN Yao qian XIA Zhi ping GAO Feng Kosuke Okada |
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| Abstract: | Tumor tissues from of different organs in ten cases with enzootic bovine leucosis were observed by eight monoclonal antibodies(McAb)those are TH14B?BAQ44A?PIg45A?BIg715A?PIg501E?cAcT105A?MM1A?AH CC125 in this experiment.The results are that 10 cattle were diagnosed as enzootic bovine leucosis by clinical pathology and the agar gel immunodiffusion.The tumor tissues of nine cases had the strong staining reaction for the McAb attribute of B cell.It indicated that thhe tumor cells origin from B cell.The tumor tissues of only one cases had the strong staining reaction for the McAb attribute of T cell.It is considered that the origin of tumor cells relative to T cell in this case. |
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| Keywords: | enzootic bovine leucosis monoclonal antibody B cell T cell |
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