The effect of various antibacterial preparations on the in vitro morphology and chemotactic response of equine neutrophils |
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| Authors: | J. F. PYCOCK W. E. ALLEN D.J. PORTER E. H. BOYD |
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| Affiliation: | Department of Surgery and Obstetrics, Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire, U.K. |
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| Abstract: | Two independent assay systems were used to study the effect of three antibacterial preparations on in vitro morphology and chemotaxis of equine neutrophils. Incubation of neutrophils with high (200 micrograms/ml) and medium (20 micrograms/ml) concentrations of neomycin impaired their response to standard chemoattractants. Trimethoprim/sulfadoxine (0.4/2.0 micrograms/ml-40/200 micrograms/ml) and benzylpenicillin (0.25-25 micrograms/ml) had no effect. Neutrophils collected from geldings 2 and 24 h after neomycin (5 mg/kg) administration had impaired responses to standard chemoattractants. Benzylpenicillin (13.2 mg/kg) had no effect. |
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