| 中年C57BL/6和ICR小鼠感觉运动能力的改变 |
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| 引用本文： | 曹磊,王芳,黄德武,邓廿庆,顾秀萍,陈贵海. 中年C57BL/6和ICR小鼠感觉运动能力的改变[J]. 安徽农业大学学报, 2009, 36(1) |
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| 作者姓名： | 曹磊 王芳 黄德武 邓廿庆 顾秀萍 陈贵海 |
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| 作者单位： | 安徽医科大学第一附属医院神经内科,合肥,230022;安徽医科大学实验动物中心,合肥,230032;安徽医科大学科技处,合肥,230032 |
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| 基金项目： | 国家自然科学基金，安徽省高校省级自然科学研究重大项目 |
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| 摘 要： | 探讨中年C57BL/6和ICR小鼠感觉运动能力的改变及实验装置对结果的影响.结果表明在10 mm和14 mm直径钢质平衡杆上,中年C57BL/6小鼠的平衡时间缩短,且雌鼠和雄鼠在10 mm直径钢杆上均可显示年龄效应.中年C57BL/6小鼠在紧绳实验中的悬挂时间和转换分也减少,但仅转换分在雄鼠显示年龄效应;中年ICR鼠在6 mm和14 mm直径钢杆上的平衡时间延长,且雌鼠和雄鼠在2种钢杆上均可显示年龄效应,但紧绳任务的悬挂时间和转换分均无年龄和性别差异.这些结果提示中年小鼠有感觉运动能力改变,但改变模式因任务和品系而异,平衡木的大小和形状影响年龄效应检测的有效性.
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| 关 键 词： | 衰老 行为 小鼠 感觉运动 性别 |
Changes of sensorimotor abilities in middle-aged C57BL/6 and ICR mice |
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| CAO Lei,WANG Fang,HUANG De-wu,DENG Nian-qing,GU Xiu-ping,CHEN Gui-hai. Changes of sensorimotor abilities in middle-aged C57BL/6 and ICR mice[J]. Journal of Anhui Agricultural University, 2009, 36(1) |
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| Authors: | CAO Lei WANG Fang HUANG De-wu DENG Nian-qing GU Xiu-ping CHEN Gui-hai |
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| Affiliation: | 1.Department of Neurology;the First Affiliated Hospital of Anhui Medical University;Hefei 230032;2.Experimental Animal Center;Anhui Medical University;3.Research Administration Office;Hefei 230032 |
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| Abstract: | We explored the changes of sensorimotor abilities in middle-aged C57BL/6 and ICR mice and the effect of different experimental devices on the performance.The results indicated that for the middle-aged C57BL/6 mice,the balance time decreased in the 10-and 14-mm diameter steel rods,and both male and female mice showed age effect on the 10-mm diameter steel rod.As to the tightrope task,the suspension time and transformed score declined for this kind of mice too,but only male mice showed the age effect on trans... |
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| Keywords: | aging behavior mouse sensorimotor sex |
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