Dopamine inhibits gonadotropin secretion in the Chinese loach (Paramisgurnus dabryanus) |
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| Authors: | Hao-Ren Lin Chun Peng Glen Van Der Kraak Richard E Peter |
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| Institution: | (1) Department of Biology, Zhongshan University, Guangzhou, People's Republic of China;(2) Department of Zoology, University of Guelph, N1G 2W1 Guelph, Ontario, Canada;(3) Department of Zoology, University of Alberta, T6G 2B9 Edmonton, Alberta, Canada |
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| Abstract: | The effects of dopamine on gonadotropin (GtH) secretion in sexually mature Chinese loach were investigated. Spontaneous secretion of GtH was inhibited within 1 h following an intramuscular injection of dopamine (100  g/g body wt). Similarly, dopamine (50 and 100 g/g body wt) caused a significant reduction in serum GtH in fish with elevated GtH levels as a result of pretreatment with gonadotropin-releasing hormone (GnRH) analogs either alone or in combination with the dopamine receptor antagonist domperidone. In summary, the present study provides direct evidence that dopamine functions as a gonadotropin-release inhibitory factor in the Chinese loach by blocking spontaneous and GnRH-stimulated GtH release. |
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| Keywords: | teleost neuroendocrine GtH release dopamine GnRH |
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