Antimicrobial resistance changes in enteric Escherichia coli of horses during hospitalisation: Resistance profiling of isolates |
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| Authors: | A Williams RM Christley SA McKane VLH Roberts PD Clegg NJ Williams |
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| Institution: | 1. Philip Leverhulme Equine Hospital, Leahurst Campus, School of Veterinary Sciences, University of Liverpool, Neston, Wirral CH64 7TE, UK;2. Department of Epidemiology and Public Health, Institute of Infection and Global Health, Leahurst Campus, University of Liverpool, Neston, Wirral CH64 7TE, UK;3. Cotts Farm Equine Hospital, Narberth, Pembrokeshire SA67 8EY, UK;4. Department of Clinical Veterinary Medicine, University of Bristol, Langford, Somerset BS40 5DU, UK;5. Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Leahurst Campus, University of Liverpool, Neston, Wirral CH64 7TE, UK;1. Department of Horse Breeding and Equestrian Studies, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland;2. Department of Surgery, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland;3. Department of Pathophysiology, Wroclaw Medical University, Wroclaw, Poland;1. Departamento de Física Aplicada, Universidad Autónoma de Madrid, Spain;2. Grupo de Bioingeniería y Telemedicina, ETSIT, Universidad Politécnica de Madrid, Spain;3. Departamento de Oftalmología, Hospital Universitario Ramón y Cajal, Madrid, Spain;4. Departamento de Biología Molecular, Universidad Autónoma de Madrid, Spain;5. Instituto de Cerámica y Vidrio-Consejo Superior de Investigaciones Científicas and IMDEA Nanociencia, Madrid, Spain;1. William R. Pritchard Veterinary Medical Teaching Hospital, University of California-Davis, 1 Garrod Dr, Davis, CA 95616, USA;2. Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, 1 Garrod Dr, Davis, CA 95616, USA;3. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, 1 Garrod Dr, Davis, CA 95616, USA |
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| Abstract: | The aim of this study was to determine whether hospitalisation of horses leads to increased antimicrobial resistance in equine faecal Escherichia coli isolates. E. coli were cultured from faecal samples of horses on admission and after 7 days of hospitalisation; antimicrobial susceptibility was determined for eight antimicrobial agents. Resistance profiles of E. coli isolates were grouped into clusters, which were analysed to determine resistance patterns. Resistance to 7/8 antimicrobial agents and multi-drug resistance (MDR; resistance to ?3 antimicrobial classes) were significantly higher after 7 days of hospitalisation. Forty-eight resistance profiles were identified; 15/48 were present on day 0 only, 16/48 on day 7 only and 17/48 at both times of sampling. There was a significant association between day 7 profiles and resistance detected to an increased number of antimicrobial agents. Hospitalisation of horses for 7 days resulted in alterations in equine faecal E. coli antimicrobial resistance profiles. |
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