The human and canine TERT promoters function equivalently in human and canine cells |
| |
Authors: | Arendt M L Nasir L Morgan I M |
| |
Affiliation: | Institute of Comparative Medicine, University of Glasgow, Glasgow, UK. maja_a@life.ku.dk |
| |
Abstract: | Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics. |
| |
Keywords: | cancer comparative oncology gene therapy Telomerase TERT |
本文献已被 PubMed 等数据库收录! |
|