植物LHP1同源基因研究进展

拟南芥LIKE HETEROCHROMATIN PROTEIN 1 (LHP1)/TERMINAL FLOWER 2(TFL2)基因被认为是后生动物HP1的同系物.在动物中,HP1通常参与异染色质形成及基因沉默.与HP1不同,LHP1定位于常染色质并抑制位于常染色质中众多基因的表达.拟南芥LHP1/TFL2突变体表现出多重表型,如早花、降低对光周期敏感性、顶端花序和植株矮小.目前对LHP1的研究特别是在单子叶植物水稻中的研究,仅限于蛋白表达谱差异,而未在基因序列及基因表达调控水平上作深入的研究.鉴于拟南芥LHP1的重要功能,今后需对LHP1同源基因在不同物种特别是单子叶植物水稻中的功能进行深入研究;此外,还应加强不同物种LHP1进化的关系分析、LHP1在不同物种整个生育期的表达谱、单子叶植物水稻中lhp1突变体的功能表达及LHP1在开花调控网络中的定位等方面的研究.

The LHP1 gene research progress

Arabidopsis LIKE HETEROCHROMATIN PROTEIN 1 （LHP1） and TERMINAL FLOWER 2 （TFL2） were identified as homolog of metazoan HETEROCHROMATIN PROTEIN 1 （HP1）. In animals， HP1 protein was involved in heterochromatin formation and gene silencing. Different from HP1， the LHP1 was usually located in euchromatin and inhibited the expression of multiple genes in euchromatin. Arabidopsis LHP1/TFL2 mutants exhibited multiple phenotypes， such as early flowering， photoperiod sensitivity reduction， apical inflorescence， and dwarf plants. The past researches conducted on LHP1， especially in monocotyledonous plant rice， was restricted to the different protein expressions， but discussed little or none about the gene sequence， gene expression， and gene regulation level for in-depth researches. Due to the importance of LHP1 functions， the LHP1 homologous genes in different species， especially monocot rice， was carefully studied and analyzed in this study. Furthermore， basing on the N-terminal sequence difference of LHP1 homologous gene in different species caused by different reasons， LHP1’s evolutionary characteristics were also analyzed. The expression of LHP1 in different species during duration， the funtional expression of LHP1 mutant in rice， and the loci of LHP1 in flowering regulating network should be studied in the future.