| H3N2亚型禽流感病毒及猪流感病毒感染人肺腺癌细胞后增殖的差异性变化 |
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| 引用本文： | 崔梦一,梁佳,黄晓量,劳婷婷,王伊玲,王晋,高灵茜,樊晓晖. H3N2亚型禽流感病毒及猪流感病毒感染人肺腺癌细胞后增殖的差异性变化[J]. 动物医学进展, 2017, 38(4) |
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| 作者姓名： | 崔梦一 梁佳 黄晓量 劳婷婷 王伊玲 王晋 高灵茜 樊晓晖 |
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| 作者单位： | 广西医科大学微生物学教研室,广西南宁,530021 |
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| 基金项目： | 广西研究生教育创新计划项目,广西医科大学青年科学基金项目 |
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| 摘 要： | 人肺腺癌细胞A549被H3N2亚型禽流感病毒和猪流感病毒感染后,探讨不同毒株跨种属感染人呼吸道组织的可能性和趋势性。通过观察病毒感染A549细胞后的细胞病变(CPE)、血凝试验(HA)和50%组织细胞感染量(TCID50)来比较不同毒株感染细胞后的复制差异和毒力改变,发现同一亚型不同来源的流感病毒对A549细胞感染和复制能力有较大差异,哺乳动物来源的病毒更有感染人呼吸道细胞的趋势,SW/GX/NS2783/2010有潜在的感染人细胞的能力。感染过程中的细胞因子变化和病毒基因组组成特点是进一步研究的方向,应重点关注具有跨种属感染趋势的流感病毒及其特殊分子决定簇的组成和特点。
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| 关 键 词： | H3N2亚型流感病毒 猪流感病毒 禽流感病毒 人肺腺癌细胞 |
Replication Diversity of H3N2 Avian Influenza Virus and Swine Influenza Virus after Infecting A549 Cells |
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| CUI Meng-yi,LIANG Jia,HUANG Xiao-liang,LAO Ting-ting,WANG Yi-ling,WANG Jin,GAO Ling-xi,FAN Xiao-hui. Replication Diversity of H3N2 Avian Influenza Virus and Swine Influenza Virus after Infecting A549 Cells[J]. Progress In Veterinary Medicine, 2017, 38(4) |
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| Authors: | CUI Meng-yi LIANG Jia HUANG Xiao-liang LAO Ting-ting WANG Yi-ling WANG Jin GAO Ling-xi FAN Xiao-hui |
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| Abstract: | To discuss the possibility and trend of the infection in human respiratory tissues with different strains of H3N2 influenza virus,CPE,HA and TCID50 were compared after A549 cells were infected with the H3N2 avian influenza virus and swine influenza virus.The results showed that the infection and replication abilities of different sources of H3N2 viruses had more diversities.Mammal-origin viruses had more tendencies to infect the human respiratory tract cells,SW/GX/NS2783/2010 had the potential ability to infect humans.Further studies are needed to explore the characteristics and composition of viral genome and the changes of cytokines in the infection process,especially some special molecular determinants of influenza virus. |
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| Keywords: | H3N2 influenza virus Swine influenza virus Avian influenza virus A549 cell |
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