Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction |
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| Authors: | Ali Elham H A Arafa Nadia M S |
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| Affiliation: | a Zoology Department, Women College, for Arts, Science and Education, Ain Shams University, Cairo, Egypt;b Physiology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt |
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| Abstract: | The comparative preventive effect of curcumin, memantine, and diclofenac on scopolamine-induced memory dysfunction was investigated in a controlled study. A group of male and female rats was treated with one of these compounds for 15 days, after which a single dosage of scopolamine was administered. The preventive activity of curcumin on memory dysfunction was higher than that of diclofenac or memantine, that was, however, administered at lower dosages. Gender differences were observed. |
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| Keywords: | Curcumin Memantine Memory dysfunction Acetyl-cholinesterase Na+ K+ ATPase Amino acid neurotransmitters |
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