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A new cytotoxic guaianolide from Chrysanthemum boreale |
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| Authors: | Park Ki Hun Yang Min Suk Park Moon Ki Kim Sang Chan Yang Chae Ha Park Sook Jahr Lee Jong Rok |
| Institution: | Division of Applied Life Science (BK21 program), EB-NCRC, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea. |
| Abstract: | A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested. |
| Keywords: | Chrysanthemum boreale Makino Guaianolide 8-acetoxy-4 10-dihydroxy-2 11(13)-guaiadiene-12 6-olide Cytotoxic activity |
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