卡介苗与结核菌野毒株的基因差异的研究进展

人类结核已经存在数千年之久,无一个国家能幸免于难,尤其是第三国家。人们在感染结核病的同时也能感染艾滋病,这给人类的健康带来了巨大的挑战。现阶段,预防结核病的唯一方法就是接种BCG-减毒牛型结核分枝杆菌活疫苗。该疫苗是在1908年,由Leon Calmette和Camile Guerin将一株牛型结核分枝杆菌强毒株经历13年230次传代培养,使其毒力发生变异,成为对人无致病性,而保持了良好的免疫原性的菌株。本文主要是探讨结核分枝杆菌,牛型结核分枝杆菌和卡介苗之间的基因的差异。为卡介苗的改良和结核病的检测提供有益借鉴。

Progresses on the Gene Difference between BCG and Wild Strains of Mycobacterium Tuberculosis

Tuberculosis has existed for thousands years and each country has infected with TB, especially in third countries, people infected with both TB and HIV. It bring a great challenge for human＇s health safety. Now, the best way to prevent tuberculosis is BCG-Mycobacterium bovis attenuated strain. In 1980, by Leon Calmette and Camile Guerin, virulent strain of Mycobacterium tuberculosis through 13 years of 230 subculture obtain BCG. BCG virulence had changed, non-pathog- enic for hunman and maintain good immunogenicity. This article is study the gene difference betweenMycobacterium tuberculosis, Mycobacterium bovis and BCG. for modified of BCG and detection of TB provide help.