HEMOPOIETIC RESPONSES OF THE CAT TO TOTAL BODY IRRADIATION FOLLOWED BY CHEMOTHERAPY |
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Authors: | Michael A. Walker DVM J. B. Jones DVM |
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Affiliation: | College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-4500, where Dr. Walker is Associate Professor in the Department of Urban Practice and Dr. Jones is Professor in the Department of Environmental Practice. |
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Abstract: | Cats with lymphosarcoma are affected with rapidly progressive, fatal neoplasia of hemopoietic tissues. The very aggressive nature of this type of neoplasia requires intense therapy, which in most instances is only palliative. A combination of total body irradiation and cytotoxic chemotherapy in four normal cats was followed by similar patterns of leukopenia and throm-bocytopenia in all cats. The radiation protocol and the complications of the transient throm-bocytopenia and leukopenia are discussed and compared with reports of similar efforts in human medicine. The responses from these normal cats were quite similar to those seen in humans undergoing similar therapy. The cat may be considered as a possible model for further radiotherapy research. |
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Keywords: | hemopoietic total body irradiation cat veterinary medicine |
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