Immune responses to haemorrhagic septicaemia (HS) vaccination in <Emphasis Type="Italic">Trypanosoma evansi</Emphasis> infected buffalo-calves |
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Authors: | Lachhman D Singla Prayag D Juyal Narinder S Sharma |
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Institution: | (1) Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India;(2) Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India;(3) Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India |
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Abstract: | To assess the immunosuppressive effect of Trypanosoma evansi infection in buffalo-calves on immune responses to heterologous antigen, the study was planned to examine the responses of
haemorrhagic septicaemia vaccination in simultaneously and previously (80 days before vaccination) T. evansi-infected buffalo-calves. Eight buffalo-calves were divided into three groups. Buffalo-calves of group A (n = 3) were previously (80 days before primary vaccination with haemorrhagic septicaemia HS] vaccine) infected with T. evansi (1 × 107 tryps.calf−1; sc) and that of group B (n = 3) were infected with T. evansi
(1 × 107 tryps.calf−1; sc) on the day of primary vaccination with HS vaccine. Two healthy uninfected control calves given only HS vaccine were
kept in group C. All the buffalo-calves were given a booster dose of vaccine 21 days post-primary vaccination (PPV). Twenty
eight days PPV, animals of group A were given trypanocidal quinapyramine prosalt at 6.66 mg kg−1. Immunosuppressive effect of T. evansi infection was evident from day 7 PPV with HS vaccine. The effect was more pronounced in previously T. evansi-infected buffalo-calves as compared with simultaneously infected buffalo-calves. Group A buffalo-calves appeared to have
recovered from the immunosuppressive effect after 28 days post-trypanocidal treatment as observed by humoral and cell-mediated
immune responses. Immunosuppressive effect to HS vaccination was observed in T. evansi-infected buffalo-calves, and trypanocidal therapy enabled the calves to mount the responses similar to uninfected controls. |
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