Antifungal limonoids from the fruits of Khaya senegalensis |
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Authors: | Abdelgaleil Samir A M Iwagawa Tetsuo Doe Matsumi Nakatani Munehiro |
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Affiliation: | Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University, Alexandria, Egypt. samir@chem.agri.kagoshima-u.ac.jp |
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Abstract: | Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named seneganolide A (1), 2-hydroxyseneganolide A (2) and 2-acetoxyseneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and methyl 6-hydroxyangolensate (5), were also found. The structures of the new compounds were elucidated on the basis of spectral methods. The antifungal activity of compounds 1, 3 and 5 was tested against the fungus Botrytis cinerea. |
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