Effect of tetracycline combined with anti-inflammation drug and tetracycline on the level of serum IgG antibody titer in early-onset periodontitis

AIM: The purpose of this study was to evaluate the effect of tetracycline combined with anti-inflammation drug on the serum antibody level against porphyromonas gingivalis (Pg) in patients with early-onset periodontitis (EOP). METHODS: The study population consisted of 12 individuals with early-onset periodontitis, 16 patients with adult periodontitis (AP) and 12 periodontally healthy subjects (HS). Clinical examination and recordings of probing pocket depth (PPD), periodontal attachment level (PAL) and bleeding on probing (BOP) were performed prior to treatment and at three months following the periodontal treatment. The serum antibody titer against Pg in patients with EOP was measured at diagnosis and at the termination of treatmeat. RESULTS: A significant improvement was observed in probing pocket depth, periodontal attachment level and gingival bleeding index post treatment for three months. The serum IgG antibody titer against porphyromonas gingivalis was decreased significantly after the treatment. CONCLUSION: Our results demonstrate that mechanical periodontal treatment combined with tetracycline and anti-inflammation drug provides clinically favorable results in patients with early-onset periodontitis.