Effects of Sini decoction on the expression of TGF-β1 in balloon injured iliac artery of rabbits |
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| Authors: | LIU Yong QIAN Xiao-xian WU Wei-kang ZHOU Bin CHEN Lin LIU Jin-lai |
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| Affiliation: | 1.Department of Cardiology, The Third Affiliated Hospital， Sun Yat-sen University, Guangzhou 510630, China. E-mail:xiaoxianq@tom.com;2.Institute for Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University, Guangzhou 510080, China |
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| Abstract: | AIM:To investigate the effect of Sini decoction (SND) on vascular stenosis and the expression of transfoming growth factor-β1 (TGF-β1) in iliac artery balloon injured rabbits. METHODS:24 male New Zealand albino rabbits were divided into three groups:control group, model group and SND treatment group. The iliac arteries were injured by balloon in model and SND groups. Four weeks later, serum TGF-β1 level was assayed by ELISA. Endothelial hyperplasia, TGF-β1 protein and mRNA expression were observed in injured iliac artery. RESULTS:Light microscope showed that the vascular lumina were narrower, intima was thicker in model group control and SND treatment group. The serum TGF-β1 level was lower in control than model group and SND treatment group, and the serum TGF-β1 level in SND treatment group was lower than that in model group. Immunohistochemistry and RT-PCR results showed that TGF-β1 protein and mRNA expression was lower in rabbit iliac artery of control group than that in model group and SND treatment group, and the expression of TGF-β1 protein and mRNA decreased significantly in SND treatment group compared with model group. CONCLUSION:SND could lessen intimal hyperplasia and vascular stenosis in balloon injured iliac artery, which might be related to decrease in TGF-β1 protein and gene expression in iliac artery. |
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