Relationship between RUNX3,cyclin E,P21 and survival in gastric cancer patients |
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Authors: | CHEN Jin-ming GAN Jian-xin YU Chun-zhao WANG Shen-hua WU Jun-song YI Jian-hua YANG Jian-xin ZHOU Hai-bo |
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Institution: | 1.Department of Surgery,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China,E-mail: zhouhaibohz@163.com;2.Department of Surgery,Jiangsu Provincial Hospital,Nanjing 210029,China |
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Abstract: | AIM:To evaluate the relationship between RUNX3,cyclin E,P21,biological features and survival in gastric cancer patients.METHODS:RUNX3 was examined using immunohistochemical staining.Cyclin E and P21 were analyzed by flow cytometry.Survival was evaluated by Kaplan-Meier survival curves.RESULTS:The positive-expression rate of RUNX3,cyclin E and P21 in tumor tissue from 56 patients with gastric cancer were 44.6%,64.3% and 32.1%,respectively.RUNX3 expression was correlated with lymph node metastasis and distant metastasis (P<0.05).Cyclin E might be related to depth of invasion,lymph node metastasis and distant metastasis (P<0.05).P21 was correlated with lymph node metastasis (P<0.05).It was revealed that RUNX3 and P21 were correlated (r=0.57,P<0.05),no correlation between RUNX3 and cyclin E was observed (r=0.25,P>0.05).Using Kaplan-Meier survival curves and the Log-rank test,there was correlation between RUNX3,cyclin E and survival (P<0.05).No correlation between P21 and survival was observed (P>0.05).CONCLUSION:RUNX3 may be related with tumorigenesis and tumor progression by affecting P21 expression.The detection of RUNX3 and cyclin E may be helpful in evaluating the clinicopathological parameters and prognosis in gastric carcinoma patients. |
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Keywords: | Stomach neoplasms Genes RUNX3 Protein p21 Survival Cyclin E |
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