Changes of serum levels of inflammatory cytokines in elderly patients with heart failure |
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Authors: | CHEN Huan-qin TAN Hong-yong LIU Xiang-qun LIU Chuan-liang |
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Institution: | 1.Department of Health Care, Qilu Hospital of Shandong University, Jinan 250012, China;2.Department of Health Care, People’s Hospital of Weifang City, Weifang 261041, China |
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Abstract: | AIM: To investigate the relationship between serum levels of TNF-α, sTNFRI, IL-6, IL-10, TGF-β1 and cardiac function in elderly patients with heart failure.METHODS: The serum levels of TNF-α, sTNFRI, IL-6, IL-10 and TGF-β1 were determined by ELISA in 112 elderly patients with heart failure and 60 elderly normal subjects.The left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were measured by color Doppler ultrasonic instrument.RESULTS: (1) Compared with normal subjects group, the serum levels of TNF-α, sTNFRI, IL-6, IL-10 and TGF-β1 in elderly patients with heart failure were significantly elevated (P<0.05 or P<0.01), and increased gradually with upgrade of cardiac function according to cardiac function classification of New York Heart Association (P<0.05 or P<0.01).(2) The ratio of TNFα/sTNFRI and IL-6/IL-10 in patients with heart failure were notably higher than those in control (P<0.05, P<0.01) and increased gradually with upgrade of cardiac function classification (P<0.05, P<0.01).(3) In heart failure group, a significantly positive correlation was found between serum levels of TNF-α, IL-6 and LVEDD.A significantly negative correlation between serum levels of TNF-α, IL-6 and LVEF was also observed.CONCLUSION: The serum levels of pro-inflammatory cytokines are closely related with cardiac function in elderly patients with heart failure.The balances of TNFα/sTNFRI and IL-6/IL-10 shifted towards inflammatory side.Furthermore, the changes of them reflect the varieties of cardiac function. |
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