Expression of scavenger receptor B1 (SR-B1) in the liver of high fat and sugar diet-induced diabetic mice |
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Authors: | LI Li ZHANG Jin ZHOU Yi-jun PENG Yang LIU Cong MENG Xin |
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Institution: | 1.Department of Endocrinology, the Second Affiliated Hospital of China Medical University Shenyang 110004, China;2Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang 110001, China |
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Abstract: | AIM: To investigate serum lipid and the expression of SR-B1 in the livers of diabetic mice. METHODS: Ten normal diet, female C57BL/6J mice, fifteen high fat and sugar diet female C57BL/6J mice, five fed 8 weeks and ten fed 16 weeks were used in the experiment. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), insulin (INS) and the expression of SR-B1 in the livers were measured. RESULTS: 1. In the high fat and sugar diet mice, serum TC and FBG at 16 weeks were significantly higher than that in normal diet mice (P<0.05). 2. The expression of SR-B1 protein in the liver of high fat and sugar diet mice was the higher than that in normal mice, and the SR-B1 expression in the liver of the mouse fed 16 weeks was also higher than that fed 8 weeks. CONCLUSION: The expression of SR-B1 protein in the liver of type 2 diabetes mice is higher than that in normal mice, perhaps it is related to the decrease in serum HDL-C. |
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