Experimental studies on anti-atherosclerosis effects of Momordica charantia L in rabbits |
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Authors: | WANG Zuo LU Yun-cheng TANG Chao-ke YAO Feng WANG Zong-bao LIU Lu-shan YI Guang-hui YANG Yong-zong |
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Institution: | Institute of Cardiovascular Disease Research, Nanhua University, Hengyang 421001, China |
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Abstract: | AIM: Anti-atherosclerosis effects of Momordica charantia L was further studied in a New Zealand rabbit atherosclerotic model at the basis of anti-inflammation and antioxidant effects. METHODS: Animals were divided into 3 groups: normal group (normal rabbit diet), atherosclerosis group(diet containing 2% cholesterol), and Momordica charantia L group(diet containing 2% cholesterol and 1.5% sarcocarp of Momordica charantia L ). Ninety days later, all animals were sacrificed. The effect of Momordica charantia L on atherosclerosis was evaluated by measuring serum lipid and total cholesterol content of artery wall, observing fatty liver degree, aorta arteriosclerotic area, and the thickness of intima. RESULTS: The level of total serum cholesterol and LDL-C in Momordica charantia L treatment group were obviously lower than those in atherosclerosis group, so were the total cholesterol content of artery wall, fatty liver degree, atherosclerotic area, intima thickness and I/M ratio, but no significantly difference was found between the two groups in TG level. The level of HDL-C in Momordica charantia L treatment group was evidently lower than that in normal control group. CONCLUSION: Momordica charantia L has an anti-atherosclerosis action in rabbits. |
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Keywords: | Momordica charantia Arteriosclerosis Fatty liver Rabbits |
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