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Overexpression of CLN3 gene in human ovarian carcinoma |
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| Authors: | MAO Dong-wei ZHAO Yi-ping LI Ke-shen WANG Xiao-ming |
| Affiliation: | 1.Department of Gynecology & Obstetrics, 211 Hospital of PLA, Harbin 150080, China;2.The Second Affiliated Hospital,3Department of Pathophysiology, Harbin University of Medical Science, Harbin 150086, China |
| Abstract: | AIM: To determine whether overexpression of CLN3 is involved in the tumorigenesis of ovarian cacinoma. METHODS: 10 specimens of ovarian carcinoma were screened for CLN3 gene expression level by semiquantitative RT-PCR and Western blotting. RESULTS: Overexpression of CLN3 mRNA and protein was found in all ovarian tumor tissues as compared with normal tissues. CONCLUSION: The overexpression of CLN3 may contribute to tumor development of ovarian cancer. |
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