Celecoxib induces apoptosis in COX-2 non-expression gastric cancer cells |
| |
Authors: | PANG Rui-ping HU Pin-jin ZENG Zhi-rong CHEN Wei |
| |
Affiliation: | Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China |
| |
Abstract: | AIM: To investigate whether celecoxib induces gastric cancer cell apoptosis in a COX-2 non-expression cell line. METHODS: The COX-2 protein was examined by western blotting. Fluorescence microscopy, DNA agarose gel electrophoresis and flow cytometry analysis were used to test apoptosis. RESULTS: COX-2 was expressed in AGS but not MGC-803 gastric cancer cell line; Selective COX-2 inhibitor celecoxib induced MGC-803 cell line apoptosis in a concentration and time-dependent manner. CONCLUSION: Celecoxib induces apoptosis in COX-2 non-expression gastric cancer cells. |
| |
Keywords: | |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
|
点击此处可从《园艺学报》下载全文 |
|