Endothelin-1 and eNOS expression in pulmonary aterioles of patients with congenital heart diseases with pulmonary hypertension |
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Authors: | KONG Xia XIANG Ru-lian HU Xing-ti GAO Bao-hui CHEN Qi FANG Zhou-xi |
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Institution: | 1.Nanjing First Affiliated Hospital, Nanjing Medical University, Nanjing 210006, China;2.Yuying Children’s Hospital,3The Second Affiliated Hospital,4Department of Pathology,5Department of Electron Microscopy, Wenzhou Medical College, Wenzhou 325027, China |
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Abstract: | AIM: To clarify the role of eNOS and ET-1 in development of pulmonary hypertension (PH) associated with congenital heart diseases. METHODS: 40 patients were randomly divided into three groups: severe or moderate PH group (group A, 12 cases), slight PH group (group B, 14 cases) and normal group (group C, 14 cases). ET-1 and eNOS were examined by using the technique of immunohistochemistry. RESULTS: ① Plasma ET-1 concentration was significantly higher in group A and B than that in group C (P<0.01). Serum NO concentration in group A and B was significantly lower than that in group C (P<0.01). ② The proliferation of medial smooth muscle cells and collagenous fibers of pulmonary arteriole in patients with PH were observed by electron microscopy. ③ ET-1 in pulmonary arteriole was significantly higher in group A and group B than that in group C (P<0.01). eNOS in pulmonary arteriole was significantly lower in group A and group B than that in group C (P<0.01). CONCLUSION: ET-1 and eNOS may play an important role in the pathogenesis of PH. |
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