抗菌肽的研究现状与展望

耐药性细菌的出现致使现有抗菌药物对细菌感染治疗的疗效低下或无效,形成的危害日益严重,迫切需要开发出新型的抗菌制剂。高效、低毒、广谱的抗菌肽作为最有希望代替抗生素的新药制剂倍受国内外科研工作者的关注,成为当前的研究热点。本文综述了抗菌肽的生物学特性,生物学活性及其作用机制,抗菌肽的筛选策略,分析了影响抗菌肽应用中存在的问题,并对其应用前景进行了展望。

Research Progress on Antimicrobial Peptides and its Development Prospect

The emergence of antibiotic-resistant bacteria make the bad or invalid therapeutic effect of the currently used antibiotics used to combat bacterial infections, which severely harm the human and animal health, and every effort to develop novel antibacterial agents are in great needed. Antimicrobial peptides have emerged as effective broad-spectrum therapeutic agents with a promising substitute for antibiotic, and antimicrobial peptides have been a primary focus of new drug research worldwide. This paper deals with an overview of the types, bioactivities, antibacterial mechanisms, selection methods. The problems in applications of the antibacterial peptides and prospects for future researches are also mentioned.