Concentration of nitrite and nonthiol nitroso compounds in tissues as a high sensitive marker of leukocyte activity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Concentration of nitrite and nonthiol nitroso compounds in tissues as a high sensitive marker of leukocyte activity

Authors:	V.?Yu.?Titov author-information" > author-information__contact u-icon-before" > mailto:vtitov@yandex.ru" title=" vtitov@yandex.ru" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,V.?G.?Vertiprakhov,O.?V.?Kosenko,V.?I.?Fisinin,M.?E.?Dmitrieva,O.?B.?Novikova,V.?A.?Petrov

Affiliation:	1.All-Russia Scientific Research and Technological Institute of Poultry Breeding,Moscow oblast,Russia;2.All-Russia Scientific Research Veterinary Institute of Poultry Breeding,St. Petersburg,Russia;3.Russian National Research Medical University,Moscow,Russia

Abstract:	This paper shows that the inflammation-induced appearance of nitrite and nonthiol nitroso compounds in the hen blood and cow milk is due to oxidation of dinitrosyl iron complexes (DNIC) and nitrosothiols (RSNO) by reactive oxygen species (ROS), which are produced by activated leukocytes. Since DNIC and RSNO are highly effective ROS scavengers, the content of nitrite and nonthiol nitroso compounds can be regarded as one of the most sensitive indicators of leukocyte activation.

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