Congenital cutaneous fibropapillomatosis without evidences of papillomavirus
infection in a Holstein-Friesian calf |
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Authors: | Yusuke TANAKA Yuka TAGAINO Shotaro NAKAGUN Takayuki MINESHIGE Kenichi WATANABE Hisashi INOKUMA Yoshiyasu KOBAYASHI |
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Affiliation: | 1)Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan;2)Research Center for Global Agromedicine, Obhiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan |
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Abstract: | A male Holstein-Friesian calf was born with multiple, cauliflower-like, pale pink cutaneous masses on the head and limbs. On histopathological examination, the cutaneous masses were diagnosed as congenital cutaneous fibropapillomatosis. Those lesions involved focal proliferation of sebaceous gland in the dermis. There were no histological findings to suggest bovine papillomavirus infection, such as the presence of intranuclear inclusion bodies, large keratohyalin granules, and koilocytosis. Furthermore, papillomaviral antigens and DNA were not detected by immunohistochemistry and polymerase chain reaction, respectively. These results suggested that there was no association between these cutaneous lesions and bovine papillomavirus infection, and the lesions were considered as harmartomatous changes. |
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Keywords: | calf congenital dermatopathology fibropapillomatosis |
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