| 单克隆抗体研究进展 |
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| 引用本文： | 刘萍,陈苗苗,刘学荣,牟克斌,黄银君.单克隆抗体研究进展[J].中国畜牧兽医,2012,39(1):67-70. |
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| 作者姓名： | 刘萍 陈苗苗 刘学荣 牟克斌 黄银君 |
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| 作者单位： | 中农威特生物科技股份有限公司,甘肃兰州 730046 |
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| 基金项目： | 甘肃省科技计划资助(1008FCCA006);中农威特研发项目(YF20101007) |
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| 摘 要： | 杂交瘤技术使鼠源单克隆抗体被广泛用于人类疾病的诊断和研究,建立了治疗性抗体的第一个里程碑。随着生物学技术的发展和抗体基因结构的阐明,应用DNA重组技术和抗体库技术对鼠单抗进行人源化改造,先后出现了嵌合抗体、人源化抗体和全人抗体,它们从不同角度克服了鼠单抗临床应用的不足,使抗体制备技术进入了一个全新的时代。
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| 关 键 词： | 单克隆抗体 鼠源性单抗 人源性单抗 |
Research Progress in Monoclonal Antibodies |
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| LIU Ping
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CHEN Miao-miao
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LIU Xue-rong
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MU Ke-bin
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HUANG Yin-jun.Research Progress in Monoclonal Antibodies[J].China Animal Husbandry & Veterinary Medicine,2012,39(1):67-70. |
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| Authors: | LIU Ping CHEN Miao-miao LIU Xue-rong MU Ke-bin HUANG Yin-jun |
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| Institution: | China Agricultural Veterinary Biological Science and Technology Co. Ltd.,Lanzhou 730046, China |
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| Abstract: | Hybridization techniques have made mouse monoclonal antibody widely use in diagnosis and research of human disease,and established the first milestone of therapeutic antibody.With the biology development and antibody genetic structure clarification,people can humanize mouse antibody with DNA recombination and antibody library which developed antibody techniques from chimeric and reshaped to human antibody.Both humanized monoclonal antibody and its derivative overcome the clinical shortage of mouse antibody from different angles,also bring a new dawn to made antibody. |
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| Keywords: | monoclonal antibody mouse monoclonal antibody human monoclonal antibody |
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