Research progress on autophagy in treatment of glioma |
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Authors: | WANG Jing-ping ZENG Ling-gong WU Shi-wu MA Li CHAI Da-min |
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Affiliation: | Department of Clinical Pathology, The First Affiliated Hospital, Department of Pathology, Bengbu Medical College, Bengbu 233000, China |
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Abstract: | Autophagy is a transport pathway from the cytoplasm to the lysosome, which is a major intracellular degradation/recycling system ubiquitous in eukaryotic cells. Autophagy regulation has achieved some gratifying results in the treatment of glioma. It is currently an exciting field of clinical development. In chemotherapy or radiotherapy, autophagy-related drugs are currently used in vitro and in vivo for treating tumors with significant effects. Autophagy inducers and inhibitors may potentially block tumor formation and enhance the anti-cancer immune response. A more comprehensive understanding of the role of autophagy in different stages of glioma development may guide the development of new therapeutic strategies. |
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Keywords: | Autophagy Glioma Temozolomide Chloroquine PI3K/Akt/mTOR signaling pathway |
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