引起犊牛腹泻的Nebovirus

Newbury-1 virus目前是杯状病毒科（Caliciviridae）纽布病毒属（Nebovirus）的唯一成员，常用Nebovirus（NeV）表述。NeV为单股正链RNA病毒，基因组全长为7 453~7 460 bp，是致犊牛腹泻的重要病毒。NeV的病原检测主要依靠RT-PCR和Real-time RT-PCR方法。迄今为止，NeV已经在美国、英国、巴西、土耳其等13个国家检出，具有广泛的地域分布。最近，本实验室的研究表明该病毒在我国奶牛和牦牛中广泛流行，具有独特的进化趋势，并且有新基因型毒株的出现。本文就NeV的生物学特性、流行概况、所致疾病的临床症状与病理变化、检测方法和防控措施等研究进展进行综述，以期为NeV的研究提供参考。

Nebovirus: a Diarrhea-causing Virus in Calves

Newbury-1 virus, usually designated by Nebovirus (NeV), is the only member of the genus Nebovirus in the family Caliciviridae at present. NeV is a single-stranded positive-sense RNA virus with a genome length of 7 453-7 460 bp and is an important diarrhea-causing virus in calves. The detection of NeV mainly relies on RT-PCR and Real-time RT-PCR assays. To date, NeV has been detected in 13 countries including the USA, the UK, Brazil, Turkey, etc., suggesting that NeV has been widely distributed around the world. Recently, our studies suggested that the virus has been widely circulating among dairy cows and yak in China, presenting a unique evolution trend, and new genotypes have been determined. To provide a reference for NeV research, this review describes the latest research progress on NeV, including the biological characteristics, epidemiology, clinical symptoms and pathology, detection methods, prevention and control.