| 糖肽类抗生素的研究进展 |
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| 引用本文： | 董朕,陈晨,李冰,周绪正,张继瑜. 糖肽类抗生素的研究进展[J]. 畜牧兽医学报, 2020, 51(7): 1488-1498. DOI: 10.11843/j.issn.0366-6964.2020.07.002 |
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| 作者姓名： | 董朕 陈晨 李冰 周绪正 张继瑜 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所, 农业部兽用药物创制重点实验室, 甘肃省新兽药工程重点实验室, 兰州 730050 |
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| 基金项目： | 甘肃省科技计划资助-基础研究创新群体（18JR3RA397）；国家肉牛牦牛产业技术体系（CARS-37） |
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| 摘 要： | 糖肽类抗生素,尤其是万古霉素是临床治疗耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)等多重耐药的革兰阳性菌感染的有效药物。由于糖肽类抗生素耐药性问题愈加严重,寻找和开发新的化合物应用于临床治疗变得十分紧迫。本文就糖肽类抗生素的作用与耐药机制、新批准的糖肽类抗菌药物、化学修饰与新的筛选开发手段展开综述,以期对糖肽类抗生素药物的开发提供思路。
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| 关 键 词： | 多重耐药菌 糖肽类抗生素 化学修饰 筛选开发 |
| 收稿时间： | 2020-02-26 |
Research Progress of Glycopeptide Antibiotics |
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| DONG Zhen,CHEN Chen,LI Bing,ZHOU Xuzheng,ZHANG Jiyu. Research Progress of Glycopeptide Antibiotics[J]. Chinese Journal of Animal and Veterinary Sciences, 2020, 51(7): 1488-1498. DOI: 10.11843/j.issn.0366-6964.2020.07.002 |
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| Authors: | DONG Zhen CHEN Chen LI Bing ZHOU Xuzheng ZHANG Jiyu |
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| Affiliation: | Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China |
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| Abstract: | Glycopeptide antibiotics, especially vancomycin, are effective drugs for clinical treatment of multiple drug-resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). With the development of bacterial drug resistance, the problem of glycopeptide antibiotic resistance is becoming more and more serious, so it is very urgent to find and develop new compounds for clinical treatment. This paper reviews the action and resistance mechanism of glycopeptide antibiotics, newly approved glycopeptide antibiotics, chemical modification and new screening and development methods, in order to provide ideas for the development of glycopeptide antibiotics. |
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| Keywords: | multi-drug-resistant bacteria glycopeptide antibiotics chemical modification screening and development |
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