The sensitivity of mitochondrial Mg2+ ATPase to DDT and analogs at different temperatures |
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Authors: | EY Cheng LK Cutkomp |
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Institution: | Department of Entomology, Fisheries and Wildlife, University of Minnesota, St. Paul, Minnesota 55108 USA |
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Abstract: | Oligomycin-sensitive (O-S) Mg2+ ATPase from American cockroach muscle was more sensitive to DDT, TDE, methoxychlor, and DDE at cool temperatures than at warm temperature, thus showing a negative temperature effect. In contrast, inhibition by acaricides dicofol, chlorfenethol, and Plictran shows a positive temperature effect. Oxidative phosphorylation in a mitochondrial preparation from cockroach coxal muscle was reduced by DDT, but the reduction was greater at a higher temperature (32°C) than at a cooler temperature (22°C). In addition, Na+K+ ATPase from cockroach nerve cord showed a positive temperature effect with DDT. The inhibition by DDT was much less on Na+K+ ATPase than on O-S Mg2+ ATPase. The negative temperature effect by DDT and analogs on O-S Mg2+ ATPase parallels toxicity effects on insects and fish as reported by numerous researchers. The results provide further evidence for this energy-regulating enzyme being a critical component in the biological action of DDT. |
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