Increased cyclic nucleotides in several tissues of the cockroach and mouse following treatment with toxaphene |
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| Authors: | Keith D. Butler L.A. Crowder |
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| Affiliation: | Department of Entomology, University of Arizona, Tucson, Arizona 85721 USA |
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| Abstract: | Cylic AMP (cAMP) and cyclic GMP (cGMP) concentrations in toxaphene-treated cockroaches, Leucophaea maderae (Fab.), increased in all tissues sampled, with the greatest increases occurring at 24 hr for cAMP and 168 hr for cGMP. Asymptomatic mice treated with 112 mg/kg of toxaphene were not significantly different from controls. Symptomatic mice showed increased cAMP in all tissues examined and an increase in testicle cGMP. The greatest increases in cAMP occurred during the more advanced stages of toxaphene poisoning. |
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| Keywords: | To whom reprint requests should be addressed. |
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