| 骨骼肌特异性钙蛋白酶与蛋白质降解 |
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| 引用本文： | 张勇,邓科. 骨骼肌特异性钙蛋白酶与蛋白质降解[J]. 动物营养学报, 2011, 23(4): 542-545. DOI: 10.3969/j.issn.1006-267x.2011.04.003 |
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| 作者姓名： | 张勇 邓科 |
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| 作者单位： | 张勇,ZHANG Yong(沈阳农业大学畜牧兽医学院,沈阳,110866);邓科,DENG Ke(沈阳农业大学生物科学技术学院,沈阳,110866) |
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| 基金项目： | 国家自然科学基金"钙蛋白酶调控猪体蛋白降解的信号途径研究" |
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| 摘 要： | 骨骼肌特异性钙蛋白酶calpain-3是钙蛋白酶系统的一员,与肌细胞生成和细胞凋亡密切相关,同时也被认为参与了蛋白质降解过程.本文主要从骨骼肌特异性钙蛋白酶的结构功能和生理活性,并结合近年来国际上的研究成果来分析骨骼肌特异性钙蛋白酶在骨骼肌蛋白质降解中的作用.
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| 关 键 词： | 骨骼肌特异性钙蛋白酶 肌联蛋白 蛋白质降解 |
Skeletal Muscle-specific Calpain and Protein Degradation |
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| ZHANG Yong,DENG Ke. Skeletal Muscle-specific Calpain and Protein Degradation[J]. CHINESE JOURNAL OF ANIMAL NUTRITION, 2011, 23(4): 542-545. DOI: 10.3969/j.issn.1006-267x.2011.04.003 |
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| Authors: | ZHANG Yong DENG Ke |
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| Affiliation: | ZHANG Yong1 DENG Ke2(1.College of Veterinary and Animal Science,Shenyang Agricultural University,Shenyang 110866,Chian,2.College of Biological Science and Technology,China) |
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| Abstract: | Calpain-3,also named as skeletal muscle-specific calpain,is a member of the calpain system.Calpain-3 has been shown to be involved in myogenesis and apoptosis,and it also plays a role in protein degradation.This article mainly reviewed the structure,function and physiological activity of calpain-3,combined with recent international research advances,to analyze the roles of calpain-3 in skeletal muscle protein degradation. |
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| Keywords: | skeletal muscle-specific calpain titin protein degradation |
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