| (三唑基-~(14)C-)粉锈宁的标记合成 |
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| 引用本文： | 曹国印,綦立元,董雅琪. (三唑基-~(14)C-)粉锈宁的标记合成[J]. 核农学报, 1989, 3(1): 61-64 |
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| 作者姓名： | 曹国印 綦立元 董雅琪 |
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| 作者单位： | 中国农业科学院原子能利用研究所,中国农业科学院原子能利用研究所,中国农业科学院原子能利用研究所 北京 ,北京 ,北京 |
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| 摘 要： | 本文报道了(三唑基-14C)-粉锈宁的制备。由14C-甲酸和重碳酸氨基胍形成(5-14C)-3-氨基-1,2,4-三唑,再经重氮化脱氨得到(5-14C)-1,2,4-三唑,最后再与对氯酚和二氯片呐酮反应得到(三唑基-14C)-粉锈宁。放化收率为26％(从甲酸-14C计),放化纯度大于95％。
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| 关 键 词： | ~(14)C标记 杀菌剂 粉锈宁 |
| 收稿时间： | 2009-12-31 |
| 修稿时间： | 2009-12-31 |
SYNTHESIS OF FUNGICIDE (~(14)C-TRIAZOLE)-TRIADIMEFON |
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| Abstract: | The fungicide 1-(4-chloro-phenoxy-)3,3-dimethyl-1(1-H, 1,2, 4-triazollyl-) 2-butanone ( Triadimefon ) was labelled with 14C in triazole group. The synthesis was accomplished in three steps starting with 14C-formic acid and aminoguanidine bicarbonate, Formed(5-14C)-3-amino-1-H-1,2, 4-triazole was deaminated by diazotization and got(5-14C )-1, 2, 4-triazole It reacted with p-chlorophenol and 1, l-dichloro-3,3-dimethy1-2-butanone in acetone, and 14C-Triadimefon was synthesized. Radiochemical yield was 26%(based on 14C-formic acid) .Radiochemical purity was more than 95%. |
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| Keywords: | 14c labelling fungicide triadimefon |
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