Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells |
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| Authors: | Kim Hyung-Jin Jang Seon Il Kim Young-Jun Chung Hun-Taeg Yun Yong-Gab Kang Tai-Hyun Jeong Ok-Sam Kim Youn-Chul |
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| Institution: | Immunopia Research Laboratory of Molecular and Cellular Immunology, Wonkwang University, Iksan 570-749, South Korea. |
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| Abstract: | Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression. |
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