| 牛初乳酶解物对离体犊牛小肠上皮细胞增殖和吸收功能的影响 |
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| 引用本文： | 马玉敏,王恬,许若军.牛初乳酶解物对离体犊牛小肠上皮细胞增殖和吸收功能的影响[J].动物营养学报,2002,14(2):9-13. |
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| 作者姓名： | 马玉敏 王恬 许若军 |
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| 作者单位： | 1. 南京农业大学动物科技学院,江苏,南京,210095
2. 香港大学动物学系,香港 |
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| 摘 要： | 初乳经胃蛋白酶水解处理90分钟后所产生的水解物对离体犊牛小肠上皮细胞有明显的促增殖作用(P<0.01) ,而初乳经胰蛋白酶处理则不表现促增殖活性。初乳酶解物对促进细胞吸收葡萄糖的作用随着酶解处理时间的延长而逐渐增强 ,初乳经胰蛋白酶水解处理90分钟或经胃蛋白酶水解处理150分钟时的产物对细胞吸收葡萄糖的促进作用分别达到最强(P<0.01)。试验结果表明 ,初乳酶解物即小分子蛋白质(肽)具有刺激离体小肠上皮细胞增殖和功能发育的活性。
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| 关 键 词： | 初乳 酶解物 小肠上皮细胞 |
| 文章编号： | 1006-267X(2002)02-0009-05 |
| 修稿时间： | 2001年3月28日 |
EFFECTS OF HYDROLYSED BOVINE COLOSTRUM ON THE PROLIFERATION AND FUNCTIONAL MATURATION OF CALF INTESTINAL EPITHELIAL CELLS IN VITRO |
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| MA Yu-min,WANG Tian,XU Ruo-jun.EFFECTS OF HYDROLYSED BOVINE COLOSTRUM ON THE PROLIFERATION AND FUNCTIONAL MATURATION OF CALF INTESTINAL EPITHELIAL CELLS IN VITRO[J].Acta Zoonutrimenta Sinica,2002,14(2):9-13. |
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| Authors: | MA Yu-min WANG Tian XU Ruo-jun |
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| Institution: | MA Yu-min1,WANG Tian1,XU Ruo-jun2 |
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| Abstract: | Hydrolysates of bovine colostrum hydrolyzed by pepesin for 90 min significantly stimulated the proliferation of calf intestinal epithelial cells(CIEC) (P<0.01).The tryptic hydrolysates of bovine ecolostrum,however,did not display proliferation-stimulating effect at any time.Prolonged treatment of bovine colostrum by pepsin and trysin strengthened the glucose absorption.This absorption-stimulating effect of hydrolysates reached their maximum at 90 min of hydrolyzation by trypsin and 150 min by pepsin (P<0.01).The results suggested some bioactive peptides could be extracted from milk protein by suitable enzyme hydrolysis,and the hydrolysates have the function of stimulating the growth and development of intestinal epithelial cells. |
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| Keywords: | colostrum bovine colostrum hydrolysates intestinal epithelial cells |
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