Association between the findings on magnetic resonance imaging screening for syringomyelia in asymptomatic Cavalier King Charles spaniels and observation of clinical signs consistent with syringomyelia in later life |
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| Institution: | 1. Leibniz-Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, Dummerstorf 18196, Germany;2. Clinic for Cattle, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover 30173, Germany;3. Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover 30559, Germany;4. Faculty of Agricultural and Environmental Sciences, University Rostock, Justus-von-Liebig-Weg, Rostock 18059, Germany;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St., Columbus, OH 43210, USA;2. School of Health and Rehabilitation Sciences, The Ohio State University, 453 West Tenth Ave., Columbus, OH 43210, USA;3. Center for Biostatistics, The Ohio State University, 601 Vernon Tharp St., Columbus, OH 43210, USA;1. School of Life Sciences, Chongqing University, Chongqing 400030, China;2. Technical Center of Chongqing Entry Inspection and Quarantine Bureau, Engineering Research Center for Import and Export Food Safety, Chongqing 400020, China;3. Diagnostic Virology Laboratory, National Veterinary Services Laboratories, STAS/VS/APHIS/USDA, Ames, IA 50010, USA;1. Clinical Science and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK;2. Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion SG5 3HR, UK |
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| Abstract: | A questionnaire-based study was used to investigate the association between the findings on magnetic resonance imaging (MRI) screening for syringomyelia (SM) in 79 asymptomatic Cavalier King Charles spaniels (CKCS) and the subsequent development of clinical signs consistent with SM in later life. Owners reported clinical signs consistent with SM in 13/79 (16%) dogs at the time of the questionnaire. A significantly greater proportion of CKCS with a syrinx visible on MRI screening showed clinical signs in later life (9/25, 36%) than dogs without a visible syrinx (4/54, 7%; odds ratio 6.9). Whether the findings of MRI screening can be used to indicate the likelihood of an asymptomatic CKCS developing clinical signs consistent with SM in later life warrants further prospective study in a larger cohort of dogs. |
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