Suppressive effects of dichloromethane fraction from the Areca catechu nut on naloxone-precipitated morphine withdrawal in mice |
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| Authors: | Kumarnsit Ekkasit Keawpradub Niwat Vongvatcharanon Uraporn Sawangjaroen Kitja Govitrapong Piyarat |
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| Affiliation: | Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla Province, Thailand. ekumarnsit@yahoo.com |
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| Abstract: | In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period. |
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