Chemotherapy of paramphistornosis in sheep

Controlled trials were used to assess the efficacy of various anthelmintics against immature and adult paramphistomes in 75 experimentally or naturally infected sheep. Albendazole (20 mg/kg), praziquantel (10 mg/kg), nitroxynil (10 mg/kg) triclabendazole (10 and 100 mg/kg), profenophos (25 mg/kg) and netobimin (15 mg/kg) had little or no activity against adult or immature fluke. Niclosamide at 100 mg/kg had high efficacy (99%) against intestinal fluke but none against adult fluke. A 2- tertiary-butyl benzthiazole compound (CGA 72630) at 25 mg/kg and resorantel at 65 mg/kg had very high efficacy against both adult and immature fluke in the rumen and small intestine respectively. The efficacy of other anthelmintics which have been used against paramphistomes in sheep is reviewed.