Immunogenic and protective antigens of Brucella as vaccine candidates |
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| Affiliation: | 1. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, I;2. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;3. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran;1. Laboratório de Bacteriologia Aplicada, Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil;2. Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, 30190-002, Belo Horizonte, Minas Gerais, Brazil;3. Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Prices Fork Rd, Blacksburg, VA 24061, USA;1. Division of Bacteriology & Mycology, Indian Veterinary Research Institute, Izatnagar, India;2. Immunology Section, Indian Veterinary Research Institute, Izatnagar, India;1. Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, 660-701, Republic of Korea;2. Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, 430-757, Republic of Korea;3. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, Republic of Korea;4. Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Republic of Korea;1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China;2. College of Animal Science and Technology, Shandong Agricultural University, Taian, 271018, China |
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| Abstract: | Brucella is an intracellular pathogen that causes abortion in domestic animals and undulant fever in humans. Due to the lack of a human vaccine against brucellosis, animal vaccines play an important role in the management of animal and human brucellosis for decades. Strain 19, RB51 and Rev1 are the approved Brucella spp. vaccine strains that are most commonly used to protect livestock against infection and abortion. However, due to some disadvantages of these vaccines, numerous studies have been conducted for the development of effective vaccines that could also be used in other susceptible animals. In this review, we compare different aspects of immunogenic antigens that have been a candidate for the brucellosis vaccine. |
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| Keywords: | Brucellosis Vaccine candidates Immunity |
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