Characterization of Pasteurella multocida strains isolated from human infections |
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| Institution: | 1. Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, P.O. Box 18, 1581 Budapest, Hungary;2. Albert Szent-Györgyi Health Centre, Faculty of Medicine, University of Szeged, Tisza Lajos krt. 107, 6725 Szeged, Hungary;3. Department of Biotechnology, University of Szeged, Közép fasor 52, 6726 Szeged, Hungary;4. Faculty of Medicine, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, 6725 Szeged, Hungary;5. Med-Forensic Bt., Ady Endre u. 26, 6762 Sándorfalva, Hungary;1. QAAFI, The University of Queensland, St. Lucia, Qld, Australia;2. Neiker Tecnalia, Instituto Vasco de Investigación y Desarrollo Agrario, Parque Tecnológico Bizkaia Ed. 812, E-48160 Derio, Spain;3. Bovine Practitioner, Zaragoza, Spain;1. Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Spain;2. Spanish Network Research in Infectious Diseases, Department of Clinical Microbiology, Hospital Universitario 12 de Octubre, Spain;3. Exopol Laboratory, Spain;1. Department of Veterinary Disease Biology, Faculty of Medical and Health Sciences, University of Copenhagen, Stigbøjlen 4, 1870 Frederiksberg C, Denmark;2. Horsevænget, Viby, Denmark;3. Microbiology and Immunology, School of Veterinary and Life Sciences, Murdoch University, Australia;1. Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Spain;2. Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Madrid, Spain;1. Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Spain;2. Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Madrid, Spain;3. Department of Clinical Microbiology, Hospital Universitario 12 de Octubre, Spain |
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| Abstract: | Isolates of Pasteurella multocida recovered from infected humans (n = 15) were characterized by traditional and molecular microbiological methods and were compared with cat-derived strains (n = 5). The most prevalent subspecies among strains from human infections was P. multocida subsp. septica (80%), and nearly all isolates showed a similar combination of virulence-associated genes. MLST analysis classified the 20 P. multocida strains into 16 different sequence types, and we assigned 11 new sequence types (ST), however, only one of those (ST 334) was shared by two human and one cat isolates. P. multocida subsp. septica strains formed a distinct phylogenetic group within the species. The strains showed resistance to erythromycin, clindamycin and sulfamethoxazole, and with two exceptions, resistance to tilmicosin was also detected. Each strain was susceptible to ampicillin, streptomycin, gentamycin, tetracycline, doxycycline, cefazolin, cefpodoxime, chloramphenicol, florfenicol and enrofloxacin. Common characteristics (virulence profile and antibiotic sensitivity pattern) shared by strains isolated from humans and cats support the view that domestic cats may serve as a potential reservoir for P. multocida. |
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| Keywords: | Human infections Multilocus sequence typing Antimicrobial resistance |
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